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It all started in Manchester about a decade ago when the team was taking upon their first projects

FSH signaling is critical for the proliferation and functional maintenance of Sertoli cells: not only does it act synergistically with testosterone to preserve the structural integrity of the blood-testis barrier (BTB), but it also promotes lactate production by Sertoli cells, supplying crucial energy metabolic substrates for spermatogenic cells, thereby safeguarding the metabolic homeostasis of the spermatogenic microenvironment (137145)