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High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis

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71,72 At a pre-clinical level, the protective effects of vitD has been linked to enhanced innate immune production of ROS, IL-1, IFN- and cathelicidin, 73,74 while positive trials have shown a reduction in inflammatory mediators including matrix metalloproteinases (MMPs) (Table 1)

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The mechanisms by which Spirulina maxima exerts its protective effects include the modulation of inflammatory pathways and enhancement of the antioxidant defense system

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