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Crucially, the pivotal VALOR phase 3 trial did not meet its primary clinical endpoint (change in ALSFRS-R score at 28 weeks) (44)

Constitutive overexpression of the proto-oncogenes c-myb in Balb/c-3T3 cells increases expression of both IGF-1 and IGF-1R, at least partly through an increased transcriptional activity and in this way abrogates the requirement for IGF-1 in the growing media (Kim et al, 1996)

Zhang et al., Multimodal photoacoustic imaging-guided regression of corneal neovascularization: a non-invasive and safe strategy

Wedell-Neergaard, A

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