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Figure 2 Carnitine, functioning in the mitochondrial fatty acid oxidation, also plays an important role in regulating the ratio of free coenzyme A (CoA) to acyl-CoA and in the removal of excessive acyl groups ( Acetyl-L-Carnitine and Physiological Function Of the ACs in living organisms, LAC, as the most widely studied endogenous short-chain ACs, has the highest content of ACs and participates in cell anabolism and catabolism pathway ( Carnitine and Depression Increasing data seem to prove the hypothesis that carnitine levels are related to the progression of depression (Studies are summarized in Tables 1, 2)

Genetic variability plays a significant role, as differences in genes associated with oxidative stress response can impact how individuals metabolize antioxidants

Wei K, Liao X, Yang T, et al

J., Lee, W

Nat Rev Mol Cell Biol 2011;12:914

A disruption of GSH homeostasis could induce oxidative stress and lead to neurodegenerative diseases, including amyotrophic lateral sclerosis, Parkinsons disease, Alzheimers disease, and dementia, with impaired motor and cognitive functions [7]