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Higher NAD enhances SIRT1 activity, promoting fat oxidation and mitochondrial remodeling via PGC-1 pathwaysmechanisms consistent with improved endurance and recovery potential (Cant et al., Cell Metabolism

Another study on -syn showed that while the formation of recombinant -syn oligomers and fibrils does not completely prevent the function of the 20S proteasome in vitro, the stable expression of wild-type and mutant -syn in SH-SY5Y and PC12 dopaminergic cells in vitro results in a significantly higher deterioration of 20S/26S proteasomal function