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Levine GN, Frei B, Koulouris SN, Gerhard MD, Keaney JF, Vita JA

So, going back to kind of the old free radical theory of aging theory that basically the more free radicals that you have in your body or the more oxidants you have in your body the more that they are going to cause damage to different cell parts

Furthermore, although iron promotes cell division and growth, it can also lead to cell damage, as excessive iron accumulation can be toxic, activating cell death signaling pathways through oxidative stress (20)

2-HG transport into T cells is facilitated by the sodium-dependent dicarboxylate transporter (SLC13A3), altering its effector function and cell proliferation

Additionally, we induced iron accumulation in PD neurons using ferric ammonium citrate (FAC) in combination with 6-OHDA in both mono- and co-cultures to assess whether SO EO and (+)-limonene mitigated iron-mediated oxidative stress

B.ThorpeK.ChenY.et al