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[8] Patients with significant alcohol intake or thiamine deficiency also require precaution: chronic heavy alcohol use can deplete thiamine (vitamin B) and taking ALA in the setting of thiamine deficiency has been associated with serious health risks (including a condition resembling Wernickes encephalopathy)

In explaining its decision, the agency flagged concerns about complexities with regard to peptide-related impurities and active pharmaceutical ingredient (API) characterization, the potential for aggregation and a lack of human safety data

After all, this is the whole reason you were doing this procedure in the first place

High lipophilicity leads to the poor absorption of drug molecules

It falls under the S0 category of Non-Approved Substances, which is a catch-all classification for any pharmacological substance that isnt approved for human therapeutic use and is not addressed elsewhere on the list

Subcutaneous shots put B12 under the skin, in fatty tissue