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The shared pathological mechanisms discussed below are graphically summarized in Figure 1, and the corresponding molecular targets and druggable nodes are illustrated in Figure 2

PLoS Negl Trop Dis 13:e0007186

Pep4 is a selected fragment of SLPI (Secretory Leucocyte Protease Inhibitor), whereas Pep4M is a modified form in which the highly reactive cysteine residues were replaced with less reactive methionine residues

We repeated these experiments in a separate cohort of tau transgenic mice

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This powder is extremely stable, but it needs to be dissolved into a liquid solution for research