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Pande K, Chen C, Noble SM

Weakness: the GHS-R1a receptor desensitizes rapidly with repeated use (2-3 weeks), which limits long protocols

J Pharm Pract

Pontow I-M, Theil J, Diefenbacher A

This methodology opens the way to (3 S ,4 S )-3-hydroxy-4-methoxy- ( 104 ) and 3,4-dimethoxy-L-glutamic acid ( 105 ) since selective opening of the lactone ring in 95 can be accomplished by boron trifluoride etherate-catalyzed methanolysis at low temperatures to give dimethyl ester 98 (Scheme 25)