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Serum ACE1 and ACE2 levels and the ACE1/ACE2 ratio are associated with several comorbidities that can worsen COVID-19 severity, including hypertension, type II diabetes, obesity and cardiovascular disease, and in those who smoke 14

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[314] A moderate dose of caffeine enhances rapid eye movements' kinematics, such as saccade velocities and quick phases of optokinetic nystagmus, in unfatigued individuals, without affecting pursuit eye movements or visual perception, suggesting that caffeine's influence on oculomotor control may be mediated by changes in central catecholamines even in non-fatigued conditions

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