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Novel synergistic approaches combining glutaminase inhibition and redox-dependent modulation are described in this review

C156, C227, H224, and D228 in ChiEform a cysteinehistidineaspartate constellation reminiscent of a catalytic triad, located within a hydrophobic pocket (Fig

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Phosphorylation, perhaps the most studied PTM, is an ideal modification for rapid proteome relocalization, given its prevalence (most eukaryotic proteins can be phosphorylated), dynamic time scale (seconds to hours), and enzymatic specificity (Sharma et al., 2014