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Second, the PPP-generated NADPH plays a central role in the cellular metabolic network and redox homeostasis [14]

Pre-clinical findings from in vitro models indicate that ibuprofen prevents oxidative damage induced by LPS injection and better protects dopaminergic neurons against glutamate neurotoxicity than ASA (116, 117)

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Cautious use of parenteral cyanocobalamin is also recommended in patients with renal impairment, including premature neonates, because of the possibility of greater aluminum accumulation, which may cause central nervous system and bone toxicity

The reaction mixture (pH 7.0) for the assay of GSSG or (GSH + GSSG) consisted of 10 mM phosphate, 0.5 mM NADPH, 0.12 units glutathione reductase and supernatant