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Overall, our data indicate that the addition of disulfiram to chemotherapies might allow for the use of lower doses of conventional chemotherapeutic agents to achieve similar leukemia cell killing efficacy, but that effects are variable across leukemia subtypes and thus careful further preclinical evaluation is needed to identify markers that can predict response to these drug combinations

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Tsui S, Naik V, Hoa N, Hwang CJ, Afifiyan NF, Sinha Hikim A, et al

Expression and Clinical Significance of Circular RNAs Hsa_Circ_0000175 and Hsa_Circ_0008410 in Peripheral Blood Mononuclear Cells From Patients With Rheumatoid Arthritis