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Neurology 52 : 16731677

When taken orally, this protein gets broken down into its amino acids, just like any protein molecule, so studies show the complete antioxidant doesnt really make it out of digestion intact

The observation that patients with AD carrying two alleles of the APOE4 risk variant have approximately half the cerebrospinal fluid (CSF) melatonin levels compared to those with only one allele of this variant [75] could suggests that APOE4/4 carriers might particularly benefit from supplementing with exogenous melatonin

2022;8:eabq2216

MLCK is a Ca 2+ /CaM-regulated protein kinase that regulates the permeability of tight junction proteins and is a crucial enzyme in cell contraction, mediating the contraction of smooth and non-smooth muscle, thereby opening the intercellular gap and increasing the permeability of the cell barrier

This makes it one of the milder peptides with fewer side effects