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SKU: 48200017901
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Current Status of Knowledge A biochemical paradox Reference to the relation between high folate and low vitamin B-12 as a biochemical paradox was first made by the late Rene Malinow, who expressed concern at the time of the planning for the Vitamin Intervention for Stroke Prevention (VISP) Study, a randomized controlled trial that was designed to assess the effects of high-dose folic acid, vitamin B-12, and vitamin B-6 supplementation on recurrent stroke (36, 37)

This phenomenon, sometimes referred to as early worsening of diabetic retinopathy, appears to be related to the magnitude and speed of glucose lowering rather than a direct effect of the medication