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Conclusion While preliminary findings highlight the promise of PRP and PRGF as emerging, plasma-based approaches in male reproductive medicine, further research is essential to standardize protocols, evaluate long-term efficacy and safety, and elucidate underlying molecular mechanisms before these therapies can be safely and effectively translated into routine clinical practice

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Researchers and clinicians have long been attempting to appropriately utilize the dual action of HDIs to maximize the clinical benefits of herbal medicines

Pettitt SJ, Frankum JR, Punta M, Lise S, Alexander J, Chen Y, et al

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B Proc Natl Acad Sci USA 1994 91 : 62886292 Belich MP, Salmeron A, Johnston LH, Ley SC