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Journal of Autoimmunity

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Alternatively, prior to nuclear extractions, U937 cells were incubated with 10 ng ml 1 of TNF- alone or in addition to various doses of glutathione ethyl-ester (GSH-OEt, Sigma)

The fusion of cisplatin with GSH, cysteine (L(+)-Cysteine), and other proteins leads to the depletion of antioxidant reserves in the cytoplasm and causes cellular oxidative stress, which is the major mode of action of cisplatin toxicity