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The other historical doses (1 mg, 4 mg, 8 mg) remain Phase 2 / research reference points only

Today 53, 240-253 (2018)

Proc Natl Acad Sci USA 1985

During breastfeeding the infant gradually becomes vitamin B12 deficient leading to impaired, sometimes irreversible neurological development

They test four key characteristics associated with quality and safety

Vitamin B12 is essential for neurologic function, red blood cell creation, and DNA synthesis and is a coenzyme for three primary biochemical conversions: homocysteine to methionine, 5-methyltetrahydrofolate to tetrahydrofolate, and methylmalonic acid to succinyl coenzyme A [1, 2]