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Of these 30 genes, five genes, including COL2A1, IGF1, KLK3, AC002094.1, and PLG, were upregulated by MB and two genes, MMP9 and LAMC2, were downregulated by MB in EFT-412 tissues

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Furthermore, most of the potential redox modifiers described above were only efficacious in SOD1 G93A mice, and these mice do not develop the TDP-43 pathology present in almost all ALS cases