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Excess B12 from oral supplements is poorly absorbed at high doses (the body absorbs roughly 1 to 2% of a 1,000 mcg oral dose) and the remainder is excreted in urine

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Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline

B12 contributes to cell regeneration, which is essential for maintaining healthy skin

Gastric bypass surgery can reduce the stomachs ability to produce intrinsic factor, a protein needed for B12 absorption