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Further clinical trials are needed for a more precise conclusion

For individuals requiring supplementation due to confirmed deficiency or malabsorption, therapeutic doses vary considerably depending on the underlying cause: Dietary deficiency : 50150 micrograms daily orally, or cyanocobalamin tablets as prescribed Pernicious anaemia : Initially hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks, then maintenance injections every two to three months [3] Neurological involvement : More intensive regimens may be required, with hydroxocobalamin injections on alternate days until symptom improvement [3] NICE guidance emphasises that supplementation should be evidence-based rather than speculative

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B12 shots are recommended for individuals with a potential B12 deficiency, as well as individuals who feel they need additional nutritional supportespecially when oral supplements are not effective

no RCT has directly compared fasted morning versus other timing windows for subcutaneous AOD-9604.) Practical injection protocol: Dose: 250 mcg to start