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First isolated from human plasma in the early 1970s, it has since attracted sustained scientific attention for its role in a broad spectrum of biological processes

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That built-in cushion is part of why the triple agonist tolerated as well as it did despite its strength

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j , Pol II (75 nM) was incubated with DSIF and NELF (150 nM) and wild-type P-TEFb or P-TEFb(D149N) (100 nM)