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It has been observed that young adults (aged 30 years or younger), with hardly any cutaneous manifestations of NF1 (that is, fewer than 6 CaLS and no cutaneous neurofibromas) but with 2 or more subcutaneous neurofibromas are at greater risk of internal neurofibromas and this should be taken into account during follow-up.53 Although some authors have detected plexiform neurofibromas in 57% of patients who underwent full-body magnetic resonance imaging,54 there are currently no guidelines as to which patients should be monitored with these imaging studies

Initially, growth factors such as 20 ng/mL BMP2 and 30 ng/mL FGF4 were used as a control

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Rosa BA, Snowden C, Martin J, et al