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These symptoms usually disappear when drug use ceases

Within the SMA, trait and clinical measures of compulsive behaviour are related to glutamate levels, whereas a behavioural index of habitual control correlates with the glutamate:GABA ratio

We identified 25 metabolites that maximized the separation, of which l-asparagine, l-isoleucine, taurine, cADP-ribose, 5-methylthioadenosine, oxidized GSH (GSSG), GSH, symmetric dimethylarginine/asymmetric dimethylarginine (SDMA/ADMA), glycerophosphocholine, dimethylglycine, choline, dAMP, NADP, NAD, ornithine, l-valine and indole were enriched in microglia (Fig

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Burton R, Swisher SG

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