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Conclusions Both sickness behavior and ME/CFS show a phenomenological overlap, both presenting with fatigue, malaise, hyperalgesia, sleepiness, neurocognitive symptoms and mood symptoms

It also enhances the skin's ability to keep moisture, which leads to a more supple and youthful look

Unlike traditional forward and reverse genetics, which focus on one-way studies, the diagnostic strategy is characterized by a more proactive and disease-centric approach

Table 1 Searching strategy

D.L.), the Science and Technology Innovation Program of Hunan Province (2022RC4044), the Clinical Medical Research Center of Hunan Province (no.2023SK4050), the University of South China Clinical Research 4310 Program (20224310NHYCG08), Project of Hunan Provincial Health Commission (No.W20243130), the Natural Science Joint Fund of Hunan Province (2022JJ50161, 2024JJ7442) and the Science and Technology Bureau of Hengyang (202330046219)

Final thoughts Cagrilintide and semaglutide represent the next evolution in medical weight loss through dual-pathway appetite suppression and metabolic optimization