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Pharmacokinetic studies in rats demonstrated an oral bioavailability of 38.4%, with a mean Cmax of 2,252 ng/mL and terminal elimination half-lives of 3.80 1.10 hours (IV) and 6.90 1.20 hours (oral) (Awosemo et al., 2021)

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non-hydrogen substituent refers to a substituent that is not made up solely of hydrogen

10.2174/0929866524666170206122106 357 LawrenceA.BarbourR

Given the high genetic and phenotypic relevance of the available mouse models of 22q11.2DS, they provide, potentially, a unique opportunity to corroborate newly identified phenotypes in patients and to study the pathogenetic mechanisms underlying the brain-related deficits