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Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels

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doi: 10.1097/GCO.0000000000000464 45 KobayashiHYoshimotoCMatsubaraSShigetomiHImanakaS

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Annu Rev Plant Biol 66:571598

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E., Kim, H., Song, D., et al

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