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Thus, "the emerging concept of a microbiota-gut-brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders" (Cryan and Dinana, 2012)

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4.2 Non-pharmacological treatments Given the limited evidence for effective pharmacologic treatments of BIPN, adjusting dosage, timing, and administration route remains the primary strategy for reducing its incidence (Richardson et al., 2012)