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These RNCs were reconstituted with NMT1 and NAC as described for the RNCs with shorter substrate and subjected to structure determination by cryo-EM SPA (Supplementary Fig

Ensure you're following the manufacturer's instructions for injecting into subcutaneous tissue (typically the abdomen, thigh, or upper arm)

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We first looked at the thyroid-stimulating signaling by analyzing the expression of tsh- and tshr

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