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Acknowledgements We are sincerely grateful to all the staff of ShanghaiTech University and Headache Center, Beiling Tiantan Hospital, CapitaMedical University, We thank the Molecular lmaging Core Facility (MICF) at the School of Life Science and Technology, Shanghaitech Universitv for providing technical support, We thank Wei wang, Xiao Ren and Yiving liu for comments on themanuscript