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Similar to the mechanism GSTs use for catalyzation of redox reactions, the mechanism for detoxification first involves the binding of two substrates to the enzyme

Echevarria-Lima J, Rumjanek VM, Kyle-Cezar F, Harab RC, Leite AC, dos Santos Ornellas D, Moralles MM, Arajo AQ, Andrada-Serpa MJ

For example, in muscle, IRS-1 is more related to glucose uptake whereas IRS-2 stimulates the MAPK pathway [121]

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Immunohistochemistry Formalin-fixed, paraffin-embedded tissue sections (5 m) were used for haematoxylin and eosin staining and immunohistochemical analyses