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Hesperidin has also shown efficacy in the case of acute neurological pathologies such as experimental hepatic encephalopathy caused by thioacetamide [241], restoring the redox balance, as demonstrated by the decrease in MDA in both the liver tissue and the brain by increasing sirtuin-1 expression and decreasing NLPR3 and IL-1beta

Furthermore, research has linked NLRP3 inflammasome activation with HIV-associated neuropathological changes, suggesting that HIV infection can induce harmful neuroinflammatory responses in the CNS (57)

Biol Pharm Bull, 25(3):291-301

(7) Another study found that hot flashes were less severe, occurred less frequently, and lasted for a shorter amount of time in women who received daily folic acid supplements (the synthetic version of vitamin B9) for four weeks

Cell Chemical Biology, 27 (8), 9981014