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According to the substrate scope assay, the mutant was also classified as a CO since it did no longer accept tyramine and L -tyrosine (Fig

Studies have found that high oxidative stress levels (e.g., increased intracellular superoxide anion, oxidized glutathione, XO activity, etc.) and oxidative damage (e.g., elevated malondialdehyde, 8-oxodeoxyguanosine levels) in leukocytes from aged mice and peripheral blood immune cells from elderly humans are consistent with impaired immune responses

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PMID: 158 GuptaUGhoshSWallaceCTShangPXinYNairAPet al

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[DOI] [PMC free article] [PubMed] [Google Scholar] 164.Van Itallie CM, Balda MS, Anderson JM