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The use of GPX4 inhibitors in vivo (in living organisms) presents several challenges, particularly due to the risk of excessive systemic toxicity caused by nonselective inhibition of GPX4

Li J, Chen C, Xia T

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After 30 min of reperfusion, total iron and Fe 2+ levels in the tissue were the highest, the LPO product MDA also accumulated with prolonged reperfusion time, the level of reduced GSH decreased, and the level of oxidized GSSG increased (Fig

Plasma concentrations decline significantly with age, from approximately 200 ng/mL in young adults to below 80 ng/mL in older individuals