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Akathisia, copper-related catecholamine excess or overmethylation may present as severe restlessness, insomnia or compulsive behavior

The exacerbating effect of -AR on liver injury (drug-induced injury case) A study on methylphenidate induced hepatotoxicity in mice showed that the -adrenergic agonist isoproterenol significantly exacerbates liver injury, increasing the livers toxicity threshold by approximately 510 times

The release and uptake of excitatory amino acids [see comments]

Ben-Amitai D, Laron Z: Effect of insulin-like growth factor-1 deficiency or administration on the occurrence of acne

Like, there's a million variables that can throw off your blood work