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SRS 16-86, a novel ferroptosis inhibitor with high stability in plasma and liver, improves locomotor function by enhancing GPX4, GSH, and xCT levels, while reducing lipid peroxidation, gliosis, and neuronal damage in SCI models (241)

Life Science Res 8: 126132

However, the clinical evidence supporting cycling strategies specifically for glutathione remains limited, and protocols should be individualized based on professional guidance and patient response

Wolf SJ, Melvin WJ, Gallagher K (2021) Macrophage-mediated inflammation in diabetic wound repair

A number of studies have revealed that exosomes can regulate the function of target cells by secreting their contents into the TME, using crosstalk, and/or influencing major tumor-related pathways, including EMT, CSCs, angiogenesis, and metastasis involving several cell types (Wu et al., 2017)

In summary, cells of the immune system and target cells of asbestos-associated diseases exhibit oxidative stress that can be counteracted by antioxidant responses at low concentrations of asbestos fibers that are non-toxic but are overwhelmed at high fiber concentrations that may be carcinogenic or cause cell death