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The decreased malate/pyruvate and GSH levels with LbNOX expression strongly suggest a decreased cytoplasmic (free) [NADPH]/[NADP + ], while the large increase in pyruvate also strongly suggests that the pyruvate/lactate, a proxy for the cytoplasmic (free) [NAD + ]/[NADH], increased, which likely drove the lifespan extension in the females

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Local IGF-1 may imitate GH effects on germ cells since sperm motility and morphology are recorded to be improved due to IGF-1 production

Anionic liposomes for small interfering ribonucleic acid (siRNA) delivery to primary neuronal cells: evaluation of alpha-synuclein knockdown efficacy

Ramrez-Ojeda et al., 2018)

Moreover, some polyphenols can modulate the expression of some proinflammatory genes and the production of cytokines and the population of immune cells