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The utility of this stimuli-responsive platform is demonstrated through two complementary in vivo applications: tumor-targeted prodrug activation triggered by the reductive tumor microenvironment in a 4T1 breast cancer model, and repeatable, on-demand local anesthesia controlled by 405 nm light

Subsequent cell- and animal- based assays confirmed that Al 2 O 3 NPs caused mitochondria-dependent apoptosis and oxidative stress either in vitro or in vivo, which were consistent with the trends of gene regulation

Gagesch, M

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After 10 min, uptake was terminated by two PBS-CM washes followed by addition of lysis buffer (1% sodium dodecyl sulfate / 0.1 M NaOH)

Peluso, A