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It competitively binds p53, displacing endogenous FOXO4 in senescent cells (Baar et al., 2017) 24-72 hours: Freed p53 translocates to mitochondria in senescent cells, triggering the intrinsic apoptotic cascade

Sikiric et al., 2018)

Generally, however, the matter may come down to a question of scope

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Brain Volume and Vessel Presentation Brain volume and vessel presentation were proportional to the change in the brain or vessel surface area