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Instead, when an individual with mutated Fanconi anemia genes also carries the dominant-negative ALDH2*2 allele , ADH5 expression in hematopoietic tissue may be down-regulated in hematopoietic tissues, which may lead to more serious bone marrow abnormalities such as leukemia compared to patients with wild-type ALDH2*1/*1 alleles

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This approach can help sensitive individuals titrate more gradually, reducing the shock of jumping from one full dose level to the next