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309 Kallidinogenase, another microcirculation enhancer, increases capillary blood flow by generating bradykinin, leading to vasodilation and enhanced tissue perfusion

however, a crucial standard of preclinical efficacy is protection of functional outcomes

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Following this, clinical trials should include measurable clinical endpoints, such as reperfusion time, margin error rates, tumor suppression rates, intraocular pressure changes, and organ function protection

doi: 10.1016/j.cjtee.2020.02.006 10 BarberAJGardnerTWAbcouwerSF