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10.1200/JCO.2018.36.15_suppl.e13118 JCO

Effects of oral gavage with periodontal pathogens and plaque biofilm on gut microbiota ecology and intestinal tissue architecture in mice: a mechanistic study

Results After administration of the BPC-157 peptide at all doses (10 g/kg, 1 g/kg, 100 ng/kg, and 10 ng/kg), especially 14 days post-surgery, the diameter of the fistula opening was significantly reduced

Dysregulated iron homeostasis constitutes the fundamental basis for ferroptosis initiation ( 4.1 Molecular pathways governing ferroptosis cell death Iron is a critical driver of lipid peroxidation and subsequent ferroptosis within cellular environments ( Diminished activity of the cystine/glutamate antiporter (system Xc-) serves as the initial trigger for ferroptosis ( Ferroptosis substrates primarily include polyunsaturated fatty acids (PUFAs, characterized by their abundance of double bonds), free polyunsaturated fatty acids such as oxidized arachidonic acid, and adrenal hormones

When uptake is limited, cysteine usage for protein synthesis is maintained at the expense of GSH triggering ferroptosis and potentially contributing to spontaneous tumor regression in low-risk neuroblastomas

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