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In: Seminars in cancer biology

Smolders LA, Meij BP, Onis D, Riemers FM, Bergknut N, Wubbolts R, Grinwis GC, Houweling M, Groot Koerkamp MJ, van Leenen D, Holstege FC, Hazewinkel HA, Creemers LB, Penning LC, Tryfonidou MA: Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

10.1111/bjd.17195 Br J Dermatol

These deposited ICs could exert damaging effects by binding to complement receptors on innate immune effector cells and result in inflammation and tissue injury

Its a small chain of amino acids (a nonapeptide) first identified decades ago

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