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Early endosomal and lysosomal abnormalities in AD brains precede the appearance of extracellular amyloid plaques and are related to alterations of -secretase function and APP metabolism, producing longer A peptides in model cells [48] and in human brain [49]

Clinical manifestations, diagnosis and epidemiological studies of ulcerative colitis UC, first described in 1859, is usually confined to the colon, where persistent superficial inflammation of the upper mucosa of the colon develops, leading to colonic ulceration and bleeding

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These include copy number variants or larger deletions and insertions, noncoding transcripts such as lncRNAs and microRNAs as modulators of gene expression and disease, and mitochondrial gene variants 21,87

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