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Studies have confirmed that CUL5 regulates the stability of key proteins involved in cholesterol metabolism through ubiquitination (133), ultimately driving CRC cell proliferation and metastasis ( Increased CRL expression correlates with enhanced ubiquitination of PI3K/AKT signaling substrates and elevated glucose uptake/utilization (134136), warranting further investigation

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Monitor patients undergoing these procedures for signs and symptoms of neurologic impairment such as midline back pain, sensory and motor deficits (numbness, tingling, or weakness in lower limbs), and bowel or bladder dysfunction