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Intranasal delivery, used with Selank and Semax, bypasses first-pass enzymatic metabolism in some systems, which partially explains why researchers observe longer effective durations than the IV values listed in typical half-life reference data

10.1002/glia.20927 354 SchiavonA

Previous studies have shown that the stronger adsorption of O 2 on Fe-N 3 than Fe-N 4 , indicating the significantly larger oxygen affinity of pFeSAN with the unsaturated Fe-N 3 coordination than that of FeSAN with Fe-N 4 unit 37,39