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Although our study did not include a NAC-only control group, the selected dose of NAC (50 mg/kg) was based on previous studies demonstrating its safety and non-toxicity in healthy rodents [19,20,21]

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Before the intervention, 3-month-old Cyb5r3 /tetO-cre/ Sftpc -rtTA were fed doxycycline chow 14 days to induce recombination and remained on this diet for the duration of the intervention