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Experimental studies in neuropathic pain models suggest that tDCS exerts anti-inflammatory and neuroprotective effects, including the down-regulation of pro-inflammatory cytokines (e.g., TNF- , IL-1), the up-regulation of IL-10, and the suppression of microglial and astrocytic activation, thereby fostering adaptive plasticity and reducing hypersensitivity (85, 86)

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Li P, Ning Y, Wang W, Guo X, Poulet B, Wang X, Wen Y, Han J, Hao J, Liang X, Liu L, Du Y, Cheng B, Cheng S, Zhang L, Ma M, Qi X, Liang C, Wu C, Wang S, Zhao H, Zhao G, Goldring MB, Zhang F, Xu P (2020) The integrative analysis of DNA methylation and mRNA expression profiles confirmed the role of selenocompound metabolism pathway in Kashin-Beck disease

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