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Viglietto, G, Chiappetta, G, Martinez-Tello, F J, et al

Betowski et al found the impairment of both NO and EDHF in MetS rats, and this impairment probably results in unbalanced sympathetic nervous system stimulation and blood pressure elevation [43]

T., Antrobus, R

In addition, in the HepG2 cell experiment, some extrahepatic factors, such as erythroid-2-related factor 2 (NRF2) pathway [58], intestinal metabolite sodium butyrate (NaB) [59], Src homology region 2 domain-containing phosphatase-1 (SHP1)/AMPK [60], sirtuin 1 (SIRT1)/heat shock factor 1/heat shock protein (HSP) [61], and other signaling pathways have also been found to be involved in the regulation of liver lipid synthesis

Acknowledgements The authors of this work were supported financially by the Research Grants Council of Hong Hong and Tam Sai Kit Endowment Fund (Y.-C.H and K.D.K.L) and by the European Community (FP7,2007-2013) under grant agreement no