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In contrast to peripheral sensitization where reduction in pain threshold and amplification in nociceptor responsiveness occurs in the peripheral axonal terminals (Hucho and Levine, 2007), central sensitization refers to heightened nociceptor responsiveness in the CNS and spinal dorsal horn to afferent inputs, leading to hypersensitivity to suprathreshold stimuli, increased responsiveness to innocuous stimuli, and enlarged receptive fields (Woolf and Salter, 2000)

A Chi-square test was performed to determine if the data sets had a normal distribution

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At Kosmoderma, we use this evidence-based approach to customize every pigmentation treatment planwhether it involves lasers, peels, or advanced topical treatments

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